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3.中药治疗作用研究:代谢组学的方法对于研究中药的药效作用及作用物质基础具有非常明显的优势,由于其系统性、整体性的特点,代谢组学能够将中药及其方剂治疗疾病过程中生物体系内所发生的各种内源性代谢物的改变和代谢通路及途径的改变全面揭示出来。利用代谢组学研究治疗葡萄膜炎的中药及方剂,可以阐明中药及方剂治疗葡萄膜炎的作用机制及物质基础。
4.临床安全评价:代谢组学可构建评价药物毒性的技术平台,研究药物毒性作用机制,定位药物毒性靶器官,确定药物毒性剂量范围,寻找药物毒性生物标志物等,展现巨大的应用价值和广阔的发展前景。治疗葡萄膜炎的中药方剂龙胆泻肝汤中含有毒性药材木通,利用代谢组学技术研究龙胆泻肝汤,可以明确其毒性成分的生物标志物及药物毒性的作用机制,从而为准确评价药物毒性提供理论依据。代谢组学作为研究机体代谢产物变化的一种新方法,能帮助人们更好、更深人地了解生物系统对环境和基因变化的响应,为揭示复杂性疾病的机理和药物的代谢模式具有独特的优势。代谢组学通过分析血液、体液组成变化,运用计量学方法对疾病组和健康对照组进行比对分析,获取疾病诱导产生的特殊代谢产物——生物标志物,这有助于了解疾病发生、发展的机制,辅助临床诊断和治疗。与传统的疾病诊断手段相比体现了诸多优势,如标本用量少、无创伤性、快速、特异性强、敏感度高,可望找到疾病诊断特异的生物学指标。随着研究方法的不断改进、分析技术的进一步提高,代谢组学朝着整合化、自动化和高通量的方向发展,在疾病诊断方面将会有更大的突破和发展,对眼科疾病的研究,必将开启科学性和定量化研究的新水平。
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