目前正在实施的研究策略是使用针对细胞因子的单克隆抗体。尽管抗TNF疗法已成功地用于类风湿关节炎的治疗，但阻断EIU期间全身的TNF则使病情恶化［32］。其他的策略还包括：(1)使用“反义寡核苷酸”阻断RNA的转录在基因水平上调控细胞因子网络；(2)抑制参与某些细胞因子分泌的酶类(如金属蛋白酶)；(3)通过定向基因疗法将某些基因导入眼组织使其发生短暂性表达增强。然而，应该认识到的是，许多细胞因子对于网络稳态的维持可能起着重要的作用，打破这个复杂的网络将可能得到与预想相矛盾的结果。

　　基金项目：国家自然科学基金(No.39970250)、教育部霍英东教育基金会资助(No.91039)

　　作者单位：李志杰（510632　广州市，暨南大学组织移植与免疫中心眼科学教研室)

　　彭广华（510632　广州市，暨南大学组织移植与免疫中心眼科学教研室）

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