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羟基磷灰石义眼台眶内植入术后结膜脓性肉芽肿形成的原因分析

http://www.cnophol.com 2009-4-8 10:24:48 中华眼科在线

  Other Risk Factors of Pyogenic Granuloma  The style of implantation surgery, the type of orbital location of HA and the low transformation efficiency of HA are risk factors of pyogenic granuloma.

  The overtime operation, not strictly sterilizing of surgical instruments and accessories can also lead to chronic infection of HA implant. Under certain condition pyogenic granuloma may developed as a form of chronic infection of HA. Overweight or large size of the prosthesis, the low grade manufacture procedure of prosthesis and HA can increase the irritation and friction between implant and conjunctiva, which easily lead to implant exposure and infection. The low grade manufacture procedure and low transformation efficiency of HA cause partial vascularization of HA implant,although sufficient vascularization can prevent infection and rejection of HA. The shallower location of HA was not only difficult for installation of prosthesis, but also easy for HA implant exposure and infection.

  Pyogenic conjunctival granuloma, differed with simple conjunctival granuloma, can not be controlled by medical therapy effectively, and HA implants should be removed finally. The patients suffer severe hurt. So we should emphasize the prevention of pyogenic conjunctival granuloma. Long term followup will help us monitor development of pyogenic granuloma.

【参考文献】
    1 Chalasani R, Poole-Warren L, Conway RM, Ben-Nissan B. Porous orbital implants in enucleation: a systematic review. Surv Ophthalmol 2007;52(2): 145-155

  2 Yoon JS, Lew H, Kim SJ, Lee SY. Exposure rate of hydroxyapatite orbital implants a 15year experience of 802 cases. Ophthalmology 2008;115(3):566572

  3 Owji N, Sadeghipour A, Salour H, Sahraeyan N. Pyogenic granuloma as a presenting sign of hydroxyapatite orbital implant exposure: a clinicopathologic study. Ophthal Plast Reconstr Surg 2006;22(6):467471

  4 Custer PL, Trinkaus KM. Porous implant exposure: Incidence, management, and morbidity. Ophthal Plast Reconstr Surg 2007;23(1):17

  5 Park KS, Kim YS, Jo YJ. A case of anaerobic abscessed hydroxyapatite orbital implants. Korean J Ophthalmol 2001;15(1):5457

  6 Zhu YG, Zhu Y, Kang FY, Wang J. Analysis of the causes of pyogenic granuloma in hydroxyapatite orbital implants. Chin J Pract Ophthalmol 2006;24(7):692694

  7 Sadiq SA, Mengher LS, Lowry J, Downes R. Integrated orbital implantsa comparison of hydroxyapatite and porous polyethylene implants. Orbit 2008;27(1):3740

  8 Remulla HD,Rubin PA,Shore JW,Sutula FC,Townsend DJ,Woog JJ,Jahrling KV.Complications of porous spherical orbital implants. Ophthalmology 1995;102(4):586593

  9 Seiff SR, Chang JS Jr, Hurt MH, KhayamBashi H. Polymerase chain reaction identification of human immunodeficiency virus1 in preserved human sclera. Am J Ophthalmol 1994;118(4):528530

  10 Gupta M, Puri P, Rennie IG. Use of bovine pericardium as a wrapping material for hydroxyapatite orbital implants. Br J Ophthalmol 2002;86(3):288289

  11 Jordan DR, Bawazeer A. Experience with 120 synthetic hydroxyapatite implants (FCI3). Ophthal Plast Reconstr Surg 2001;17(3):184190

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