[关键词] 单纯疱疹病毒性角膜炎；银黄滴眼液
[摘 要] 目的 观察中药银黄滴眼液治疗单纯疱疹性角膜炎的临床疗效。
方法 采取随机、双盲、多中心、平行、阳性药物对照的方法，将确诊的单纯疱疹性角膜炎223例，分为治疗组112例，对照组111例。治疗组用银黄滴眼液，对照组用0.1%阿昔洛韦滴眼液，二者用药次数各自均为1次/2小时（白天用药），2滴/次，2周为一个疗程。
结果 银黄滴眼液能显著改善单纯疱疹病毒性角膜炎(风热疫毒证)所导致的畏光流泪、目干涩痛、睫状充血、角膜病变等症状，其临床疗效愈显率达85.58%，并能有效提高裸眼视力和矫正视力。另外在用药7日时，临床疗效及中医症候疗效的愈显率均优于阿昔洛韦滴眼液，具有统计学意义(P<0.05)。
结论 银黄滴眼液作为纯中药制剂比阿昔洛韦滴眼液起效快，不失为临床治疗单纯疱疹病毒性角膜炎(风热疫毒证)的安全、有效药物。
Clinical Observation on Treatment for 207 Cases of HSK with Yinhuang Eyedrop ZHAO Yu1 WU Lie1 LIANG Qiuli2
1 Ophthalmology Department of Guang’anmen Hospital, China Academy of Chinese Medical Sciences, 2 Hospital affilited to the securaty Burea of the State, Beijin 100053, China
【Abstract】Objective: To observe the curative effect of Yinhuang Eyedrop on treatment of HSK(syndrome of wind-heat-and-epidemic toxic). Methods: With RCT design of randomization, double-blind, multi-center, parallel and positive-drug control,223 patients with HSK(syndrome of wind-heat-and-epidemic toxic) were divided into two groups.112 patients as treatment group received Yinhuang Eyedrop and 111 patients as control group received 0.1％acycloviv eyedrop. Both groups received 2 drops of drug once per 2 hours in daytime, the period of treatment is 2 weeks. Results: The symptoms of photopobia, tearing, ciliary congestion, keratopathy and the sense of dry, acerbity or pain of eyes led by HSK were obviously improved,and the effective rate was 85.58% in the treatment group, both the naked-eye visual acuity and rectified visual acuity advanced by using Yinhuang Eyedrop without special adverse drug reactions.However,the effective rate both of curative effect and syndrome effect of treatment group was better than that of control group at the 7th day,there were statistical differences between the treatment group and control group(P<0.05).Conclusion: Yinhuang Eyedrop has effect rapidly than 0.1％acycloviv eyedrop. As a preparation of Chinese traditional medicine, Yinhuang Eyedrop is both effectively and safety for HSK(syndrome of wind-heat-and-epidemic toxic).
【Key words】Herpes simplex keratitis, HSK; Yinhuang Eyedrop
单纯疱疹性角膜炎是由单纯疱疹病毒引起的容易反复发作，影响视力的常见眼病。我们采用随机、双盲、多中心、平行、阳性药物对照的方法，对银黄滴眼液治疗单纯疱疹性角膜炎（风热疫毒证）进行了临床观察，客观评价，现总结如下：
1 资料与方法
一般资料 观察病例均为2005.8～2006.7经中国中医科学院广安门医院、北京大学第三医院、中日友好医院、首都医科大学附属同仁医院、河南眼科研究所、天津中医学院第一附属医院眼科门诊确诊的单纯疱疹性角膜炎，实际入组223例，对照组入组111例，完成103例（92.79％），脱落0例（0.00％），剔除8例（7.21％）；治疗组入组112例，完成104例（92.86％），脱落3例（2.68％），剔除5例（4.46）。眼别：对照组右眼52只眼（50.49%）、左眼51只眼（49.51%），治疗组右眼53只眼（49.53%）、左眼54只眼（50.47%）；性别：对照组男性51例(49.51％)、女性52例(50.49％)，治疗组男性45例(42.06％)、女性62例(57.94％)；体力劳动者对照组41例（39.81％）、治疗组34例（31.78％），非体力劳动者对照组62例（60.19％）、治疗组73例（68.22％）；平均年龄39岁；平均病程5天；诱发原因：感冒者治疗组42例、对照组43例；劳累者治疗组48例、对照组43例；复发者两组均为31例。
从一般情况看，治疗前性别、职业、年龄等人口学资料及病程、病史、诱因、病程、诊断、治疗史、诱因、合并用药各项指标组间差异均无统计学意义（P>0.05），具有可比性。两组生命体征心率、脉搏、血压组间差异均有统计意义(P<0.05)，但上述各项指标两组均处于正常值范围；呼吸组间差异无统计学意义（P>0.05）。
从症状体征看，治疗前两组眼目干涩痛症状组间差异有统计学意义(P<0.05)。但是裸眼及最佳矫正视力、畏光流泪、睫状充血、角膜病变、恶风发热等症状，舌脉象，症状体征总积分、中医证候总分组间差异均无统计学意义（P>0.05），提示可比性良好。
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