赖旗俊
林口长庚医院
Purpose:To test the efficacy and safety of a biodegradable collagen-glycosaminoglycan(CG)polymer as the material for scleral buckling in rabbit eyes.Methods：Segmental scleral buckling was performed using silicone sponge in one eye and biodegradable CG polymer in the other eye of twenty rabbits.Echography was used to evaluate the extent of the buckling effect.Electroretinograms，hisistology，immunohistochemistry and Scanning electronic microscopy was used to analyze functional and structural changes after episcleral implantation.Results：Biodegradable collagen initially achieved a buckling effect comparable to a silicone sponge;the buckling effect decreased after one month.Within 8 to 12 weeks，the collagen was gradually absorbed.The inflammatory responses were comparable between sponge and collagen in most areas of peri-buckling histology.In areas of degraded collagen，foreign body reaction was observable.Electroretinography revealed no detectable difference in retinal function between control and experimental eyes。
Conclusion:Biodegradable collagen could be used effectively and safely as the material of scleral buckling. |
