程金伟 魏锐利
第二军医大学附属长征医院眼科 200003
Objective:To evaluate the intraocular pressure(IOP)reduction achieved by the most frequently prescribed antiglaucoma drugs in patients with normal tension glaucoma(NTG).
Method:Pertinent publications were identified through electronic searches.The patients had to be diagnosed with NTG.The pooled IOP-lowering effects were calculated using DerSimonian and Laird method.
Results:Fourteen randomized clinical trials reported 23 arms for peak,14 arms for trough,and 11 arms for diurnal curve.Relative IOP reduction were 12%for a peak for betaxlol;peak,15%,trough,18%,and diurnal curve,17%for timolol;peak,14%,and trough,12%for dorzolamide;13%for a peak for brinzolamide;peak,24%,trough,11%,and diurnal curve,16%for brimonidine;peak,21%,trough,21%,and diurnal curve,21%for latanoprost;peak,21%,trough,18%,and diurnal curve,20%for bimatoprost.
Conclusions:Latanoprost,bimatoprost,and timolol are the most effective IOP-reducing agents in NTG patients. |