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9 AbuelAsrar AM, Van Damme JO, Put W, et al. Monocytochemotactic protein 1 in proliferative vitreoretinal disordors. Am J Ophthalmol 1997;123:599606
10陈慷，胡世兴，杜连心，等.单核细胞趋化蛋白1在实验性糖尿病大鼠视网膜中的表达及意义.眼科新进展 2007;27 (4) :270273
11 Van Hecke MV, Dekker JM, Nijpels G, et al. Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study. Diabetologia 2005;48:13001306
12 Christinger HW, Ferrara N, de Voss AM. Crystallization of the receptor binding domain of vascular endothelial growthfactor. Proteins 1996;26(3):353357
13 Takagi H, King GL, Aiello LP. Identification and characterization of vascular endothelial growth factor receptor (Flt) in bovine retinal pericytes. Diabetes 1996;45(8):10161023
14 Murata T, Ishibashi T, Khalil A, et al. InomataH. Vascular endothelial growth factor plays a role in hyper permeability of diabetic retinal vessels. Ophthalmic Res 1995;27(1):4852
15 Hidetaka N, Hideharu F, Hidetoshi Y, et al. Regulation of angiogenesis in diabetic retinopathy. Arch Ophthalmol 2002;120:10751080
16 Cui L, Lu H. Alteration of intraocular pigment epithelium derived factor and vascular endothelial growth factor in patients with diabetic retinopathy. Int J Ophthalmol(Guoji Yanke Zazhi) 2007;7(1):2326
17 Kon CH, Occleston NL, An ylward GW, et al. Exp ression of Vitreous cytokineines in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 1999;40:705712
18 Yoshida A, Elner SG, Bian Z, et al. Induction of interleukin in8 in human retinal pigment epithelial cells after denuding injury. Br J Ophthalmol 2001;85:872876
19 Doganay S, Evereklioglu C, Er H, et al. Comparison of serum NO ,TNFalpha , IL1beta ,sIL2R , IL6 and IL8 levels with grades of retinopathy in patients with diabetes mellitus. Eye 2002;16:163170
20 Hernandez C, Segura RM, Fonollosa A, et al. Interleukin8, monocyte chemo attractant protein1 and IL10 in the vitreous fluid of patients with proliferative diabetic retinopathy. Diabet Med 2005;22:719722
21 Sfikakis PP, Markomichelakis N, Theodossiadis GP, et al. Regression of sightthreatening macular edema in type 2 diabetes following treatment with the antitumor necrosis factor monoclonal antibody infliximab. Diabetes Care 2005;28:445447
22 Murata T, Hata Y, Ishibashi T, et al. Response of experimental retinal revascularization to thiazolidinediones. Arch Ophthalmol 2001;119:709717
23 Mori F, Hikichi T, Nagaoka T, et al. Inhibitory effect of losartan, an AT1 angiotensin Ⅱreceptor antagonist, on increased leukocyte entrapment in retinal microcirculation of diabetic rats. Br J Ophthalmol 2002;86:11721174
24 Miyahara S, Kirby J, Hampshire Kept, et al. Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocininduced diabetes. Am J Ophthalmol 2004;164:16971706
1 Aiello LP, Gardner TW, King GL, et al. Diabetic retinopathy. Diabetes Care 1998;21:14356
2 Clark JB, Grey RH, Lim KK, et al. Loss of vision before ophthalmic referral in blind and partially sighted diabetics in Bristol. Br J Ophthalmol 1994;78:741744
3 Jiang H, Kuang HY. Inflammatory cytokines and diabetic retinopathy. Intern J Endocrinal Metab 2007;27:3133
4 Miyamoto K, Khosrof S, Bursell SE, et al. Prevention of leukostasis and vascular leakage in streptozotocininduced diabetic retinopathy via intercellular adhesion molecule1 inhibition. Proc Natl Acad Sci USA 1999;96(19):1083610841
5 Ha WJ, Yan H. The role of inflammation in diabetic retinopathy. Int J Ophthalmol(Guoji Yanke Zazhi) 2005;5(4):745749
6 Joussen AM, Poulaki V, Mitsiades N, et al. Nonsteroidal antiinflammatory drugs prevent early diabetic retinopathy via TNF2alpha suppression. FASEB J 2002;16:438440
7 Taub DD. Chemokineleukocyte interactions. The voodoo that they do so well. Cytokine Growth Factor Rev 1996;7:355376
8黄晓红.MCP1及其在疾病发病中的作用.国外医学呼吸系册 1995;15:170173
9 AbuelAsrar AM, Van Damme JO, Put W, et al. Monocytochemotactic protein 1 in proliferative vitreoretinal disordors. Am J Ophthalmol 1997;123:599606
10陈慷，胡世兴，杜连心，等.单核细胞趋化蛋白1在实验性糖尿病大鼠视网膜中的表达及意义.眼科新进展 2007;27 (4) :270273
11 Van Hecke MV, Dekker JM, Nijpels G, et al. Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study. Diabetologia 2005;48:13001306
12 Christinger HW, Ferrara N, de Voss AM. Crystallization of the receptor binding domain of vascular endothelial growthfactor. Proteins 1996;26(3):353357
13 Takagi H, King GL, Aiello LP. Identification and characterization of vascular endothelial growth factor receptor (Flt) in bovine retinal pericytes. Diabetes 1996;45(8):10161023
14 Murata T, Ishibashi T, Khalil A, et al. InomataH. Vascular endothelial growth factor plays a role in hyper permeability of diabetic retinal vessels. Ophthalmic Res 1995;27(1):4852
15 Hidetaka N, Hideharu F, Hidetoshi Y, et al. Regulation of angiogenesis in diabetic retinopathy. Arch Ophthalmol 2002;120:10751080
16 Cui L, Lu H. Alteration of intraocular pigment epithelium derived factor and vascular endothelial growth factor in patients with diabetic retinopathy. Int J Ophthalmol(Guoji Yanke Zazhi) 2007;7(1):2326
17 Kon CH, Occleston NL, An ylward GW, et al. Exp ression of Vitreous cytokineines in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 1999;40:705712
18 Yoshida A, Elner SG, Bian Z, et al. Induction of interleukin in8 in human retinal pigment epithelial cells after denuding injury. Br J Ophthalmol 2001;85:872876
19 Doganay S, Evereklioglu C, Er H, et al. Comparison of serum NO ,TNFalpha , IL1beta ,sIL2R , IL6 and IL8 levels with grades of retinopathy in patients with diabetes mellitus. Eye 2002;16:163170
20 Hernandez C, Segura RM, Fonollosa A, et al. Interleukin8, monocyte chemo attractant protein1 and IL10 in the vitreous fluid of patients with proliferative diabetic retinopathy. Diabet Med 2005;22:719722
21 Sfikakis PP, Markomichelakis N, Theodossiadis GP, et al. Regression of sightthreatening macular edema in type 2 diabetes following treatment with the antitumor necrosis factor monoclonal antibody infliximab. Diabetes Care 2005;28:445447
22 Murata T, Hata Y, Ishibashi T, et al. Response of experimental retinal revascularization to thiazolidinediones. Arch Ophthalmol 2001;119:709717
23 Mori F, Hikichi T, Nagaoka T, et al. Inhibitory effect of losartan, an AT1 angiotensin Ⅱreceptor antagonist, on increased leukocyte entrapment in retinal microcirculation of diabetic rats. Br J Ophthalmol 2002;86:11721174
24 Miyahara S, Kirby J, Hampshire Kept, et al. Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocininduced diabetes. Am J Ophthalmol 2004;164:16971706
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