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Copolymer1保护视神经的作用及作用机制

http://www.cnophol.com 2009-5-7 10:10:37 中华眼科在线

  3 Teitelbaum D, Sela M, Arnon R. Copolymer1 from the laboratory to FDA. Isr J Med Sci1997;33(4):280284
  
  4 Kipnis J, Yoles E, Porat Z, et al. T cell immunity to colopymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies. Proc Natl Acad Sci U S A 2000;97(13):74467451

  5 Schori H, Kipnis J, Yoles E, et al. Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: Imlpications for glaucoma. Proc Natl Acad Sci U S A2001;98(6):33983403

  6 Bakalash S, Kessler A, Mizrahi T, et al. Antigenic specificity of immunoprotective therapeutic vaccination for glaucoma. Inv Ophthalmol Vis Sic 2003;44(8):33743381
  
  7 Bakalash S, Shilomo GB, Aloni E, et al. T cellbased vaccination for morphological and functional neuroprotection in a rat model of chronically elevated intraocular pressure. J Mol Med 2005;83(11):904916

  8 Bakalash S, Kipnis J, Yoles E, et al. Resistance of retinal ganglion cells to an increase in intraocular pressure is immunedependent. Inv Ophthalmol Vis Sci 2002;43(8):26482653

  9 Alessandri B, Bullock R. Glutamate and its receptors in the pathophysiology of brain an spinal cord injuries. Prog Brain Res 1998;116:303330

  10 Benner EJ, Mosley RL, Shaked I, et al. Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkisons disease. Proc Natl Acad Sci U S A 2004;101(25):94359440

  11 Choi DW. Glutamate neurotoxicity and disease of the nervous system. Neuron 1988;1(8):623634

  12 Schwartz M. Macrophageand microgia in central nervous system injury: are they herpful or harmful? J Cereb Blood Flow Metab 2003;23(4):385394

  13 Shaked I, Tchoresh D, Gersner R, et al. Protective autoimmunity:interferonγ enables microglia to remove glutamate without evoking inflammatory mediators. J Neurochem2005;92(5):9971009

  14 Corradin SB, Manuel J, Donini SD, et al. Inducible nitric oxide synthase activity of cloned murine microglial cells. Glia 1993;7(3):255262

  15 Kipnis J, Mizrahi T, Yoles E. Myelin specific Th1 cells are necessary for posttraumatic protective autoimmunity. J Neuroimmunol 2003;130(12):7885

  16 Kerschensteiner M, Gallmeier E, Behrens L, et al. Activatide human T cells , B cells, and monocytes produce brainderived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med1999;189(5):865870

  17 Yan Q, Elliot J, Snider WD. Brainderived neurotrophic factor rescues spinal motor neurons from axotomyinduced cell death. Nature 1992;360(6406):753755

  18 Sendtner M, Holtmann B, Kolbeck R, et al. Brainderived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section. Nature 1992;360(6406):757759

  19 Aharoni R, Meshrorer A, Sela M, et al. Oral treatment of mice with copolymer1 (glatitamer acetate) result in the accumulation of specific Th2 cells in ths central nervous system. J Neuroimmunol2002;126(12):5868

  20 Moalem G, LeibowitzAmit R, Yoles E, et al. Autoimmunity T cells protect neuron from secondary degeneration after central nervous system axotomy. Nat Med 1999;5(1):4955

  21 Barouch R, Schwartz M. Autoreactive T cells induce neurotrophin production by immune and neural central cells in injured rat optic nerve:implication for protective autoimmunity. FASEB J2002;16(10):13041306

  22 Kayahan B, Aharoni R, Arnon R. Glatiramer acetate(Copaxone) regulates nitric oxide and related cytokine secretion in experimental autoimmune encephalomyelitis. Immuno2003;88(3):185192

  23 Bakalash S, Kessler A, Mizrahi T, et al. Antigenic specificity of immunoprotective therapic vaccination for glaucoma. Invest Ophthalmol Vis Sci 2003;44(8):33743381

  24 Schwartz M. T cellbased vaccination against neurodegeneration: a new therapic approach. Retina J Ret Vit Dis 2005;25(Suppl):S3335

  25 Schwartz M. Vaccination for glaucoma: dream or reality? Brain Reserch Bulletin 2004;62(6):481484

  26 Kipnis J, Mizrahi T, Hauben E, et al. Neuroprotective autoimmunity? Naturally occurring CD4+CD25+ regulatory T cells supressthe ability to withstand injury to the central nervous system. Pro Natl Acad Sci USA 2002;99(24):1562015625

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