【摘要】 糖尿病视网膜病变(diabetic retinopathy ,DR)是糖尿病最常见、最主要的微血管并发症之一，已经成为当前全球致盲的重要原因。其基本病理改变是视网膜的血视网膜屏障的破坏和视网膜新生血管形成，黄斑水肿，最终视网膜脱离，导致失明。高血糖是公认的DR发生和发展的主要危险因素，DR还与多元醇代谢、糖基化终产物、甘油二酯蛋白激酶C系统、氧化应激和自由基、炎症反应以及细胞因子等有关，但至今其发病机制尚未完全阐明，本文就目前DR的发病机制做一系统性的综述，为DR的治疗提供新的思路。
【关键词】 糖尿病视网膜病变；发病机制；细胞因子；视网膜
Progress of research on pathogenesis of diabetic retinopathy
BaiYang Lu, ZhiFeng Wu
Department of Ophthalmology, the Second Peoples Hospital of Wuxi, Nanjing Medical University, Wuxi 214002, Jiangsu Province, China
AbstractDiabetic retinopathy (DR) is one of the most common and severe microvascular complications of diabetes and is the leading cause of acquired blindness in the working population all over the world. The breakdown of the bloodretinal barrier and neovascularization of retina are the fundamental pathological changes of DR which lead to macular edema and ultimately lead to retina detachment. Hyperglycemia is admitted to be the main risk factor in the development of DR.DR is also related to abnormal metabolism of polyol, nonenzymatic glycation, activated DG2PKC system, oxidative stress and free radical, inflammation and cell growth factors, etc. But the clear and detailed pathogenesis of DR is not elucidated. We summarized its pathologic mechanism systematically and provided ideas for treatment of DR.
KEYWORDS:diabetic retinopathy;pathogenesis;cytokine;retina
Lu BY, Wu ZF. Progress of research on pathogenesis of diabetic retinopathy. Int J Ophthalmol (Guoji Yanke Zazhi) 2008;8(11):23082311
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